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Low-dose protocols (0.250.5mg daily) are derived from studies where systemic copper peptide administration at 24 mcg/kg demonstrated follicle-stimulating activity without elevating serum copper above the normal range (70140 mcg/dL)

According to two studies analysing the evidence on B12 in plant-based foods, only the seaweeds hijiki, nori and chlorella, mushrooms, a few non-common plants and a type of fermented soya yoghurt contained some all due to bacterial activity but amounts vary with some of the samples containing no B12 (Watanabe and Bito, 2018